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Mesothelioma

Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer

Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer

Background:
Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Vaccines made from a patient's tumor tissue may make the body build an immune response to kill tumor cells. Chemotherapy combined with vaccine therapy may kill more tumor cells. This is a Phase II trial to study the effectiveness of cyclophosphamide plus tumor cell vaccine in treating patients who have metastatic cancer or cancer at high risk of recurrence.

Objectives:
+ Determine the safety and clinical effects of autologous or allogeneic active-specific intralymphatic immunotherapy with a vaccine containing interferon alfa or interferon gamma-treated tumor cells followed by sargramostim (GM-CSF) in patients with advanced cancers.

Location and Contact Information:
California
St. Vincent Medical Center - Los Angeles, Los Angeles, California, 90057-1901, United States;
Recruiting
Charles L. Wiseman, MD, FACP 213-484-7575
Study chairs or principal investigators
Charles L. Wiseman, MD, FACP, Study Chair
St. Vincent Medical Center - Los Angeles