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Mesothelioma

Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung

Erlotinib in Treating Patients With Malignant Mesothelioma of the Lung

Background:
Erlotinib may interfere with the growth of tumor cells and slow the growth of the tumor. This is a Phase II trial to study the effectiveness of erlotinib in treating patients who have unresectable malignant mesothelioma of the lung.

Objectives:

Determine the 1-year survival rate in patients with unresectable malignant pleural mesothelioma treated with erlotinib.
Determine the response rate in patients with measurable disease treated with this drug.
Determine the frequency and severity of toxic effects of this drug in these patients.
Measure epidermal growth factor receptor (EGFR) expression, EGFR gene amplification, and other activation products in the EGFR signaling pathway in tumor samples and correlate with clinical outcomes in patients treated with this drug.


Location/Contact Information:
Alabama
MBCCOP - Gulf Coast, Mobile, Alabama, 36688, United States; Recruiting
Marcel E. Conrad, MD 334-443-2233
University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, Alabama, 35294-3300, United States;
Recruiting
Rizk El-Galley, MD 205-934-0930

Arizona
Arizona Cancer Center, Tucson, Arizona, 85724, United States;
Recruiting
Michael Lobell, MD 520-626-6824
mlobell@azcc.arizona.edu


CCOP - Greater Phoenix, Phoenix, Arizona, 85006-2726, United States; Recruiting
David Kyle King, MD, FACP 602-239-2413

Veterans Affairs Medical Center - Phoenix (Carl T. Hayden), Phoenix, Arizona, 85012, United States;
Recruiting
Thomas Dale Kummet, MD 602-277-5551
Veterans Affairs Medical Center - Tucson, Tucson, Arizona, 85723, United States;
Recruiting
Thomas P. Miller, MD 520-792-1450, ext. 16631

Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205, United States;
Recruiting
Laura Fulper Hutchins, MD 501-686-8511
HutchinsLauraF@uams.edu


Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock, Arkansas, 72205, United States;
Recruiting
Bart Barlogie, MD 501-257-6820

California
CCOP - Bay Area Tumor Institute, Oakland, California, 94609-3305, United States;
Recruiting
Joseph Szumowski, MD 510-465-8570

CCOP - Santa Rosa Memorial Hospital, Santa Rosa, California, 95403, United States;
Recruiting
Leroy Wayne Keiser, MD 707-521-3830

Chao Family Comprehensive Cancer Center, Orange, California, 92868, United States;
Recruiting
Randall F. Holcombe, MD 714-456-5153
rholcomb@uci.edu

City of Hope Comprehensive Cancer Center, Duarte, California, 91010, United States;
Recruiting
James H. Doroshow, MD 626-359-8111 Ext. 62960

David Grant Medical Center, Travis Air Force Base, California, 94535, United States;
Recruiting
David R. Gandara, MD 707-423-7300

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, 90095-1781, United States;
Recruiting
John L. Barstis, MD 310-825-5268

University of California Davis Medical Center, Sacramento, California, 95817, United States;
Recruiting
David R. Gandara, MD 916-734-3772

Veterans Affairs Medical Center - West Los Angeles, Los Angeles, California, 90073, United States;
Recruiting
Charles M. Haskell, MD 310-268-4023

Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, 94553, United States;
Recruiting
David R. Gandara, MD 925-372-2064

Colorado
University of Colorado Cancer Center, Denver, Colorado, 80010, United States;
Recruiting
Scott I. Bearman, MD 303-372-9000
Veterans Affairs Medical Center - Denver, Denver, Colorado, 80220, United States;
Recruiting
Madeleine A. Kane, MD, PhD 303-393-4698

District of Columbia
MBCCOP-Howard University Cancer Center, Washington, District of Columbia, 20060, United States;
Recruiting
Lucile L. Adams-Campbell, PhD 202-806-7697

Georgia
CCOP - Atlanta Regional, Atlanta, Georgia, 30342-1701, United States; Recruiting
Thomas E. Seay, MD, PhD 404-851-2340
Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia, 30905-5650, United States;
Recruiting
Kenneth I. Fink, MD 706-787-2527
kenneth.fink@se.amedd.army.mil 


Hawaii
Cancer Research Center of Hawaii, Honolulu, Hawaii, 96813-2424, United States; Recruiting
Brian F. Issell, MD 808-586-3013
brian@crch.hawaii.edu


Tripler Army Medical Center, Honolulu, Hawaii, 96859-5000, United States; Recruiting
Brian F. Issell, MD 808-433-4089

Illinois
CCOP - Central Illinois, Decatur, Illinois, 62526, United States; Recruiting
James L. Wade, MD 217-876-6618
Loyola University Medical Center, Maywood, Illinois, 60153, United States; Recruiting
Ellen R. Gaynor, MD 708-327-3101

MBCCOP - University of Illinois at Chicago, Chicago, Illinois, 60612-7323, United States;
Recruiting
Thomas E. Lad, MD 312-996-7976

Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago, Illinois, 60612, United States;
Recruiting
Thomas E. Lad, MD 312-666-6500 ext. 2442

Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines, Illinois, 60141, United States;
Recruiting
Nirmala Bhoopalam, MD 708-202-8387 ext. 1430

Kansas
CCOP - Wichita, Wichita, Kansas, 67214-3882, United States; Recruiting
Shaker R. Dakhil, MD 316-262-4467
Veterans Affairs Medical Center - Wichita, Wichita, Kansas, 67218, United States;
Recruiting
Shaker R. Dakhil, MD 316-685-2221

Kentucky
Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, 40536-0084, United States;
Recruiting
Michael A. Doukas, MD 859-257-4500

Veterans Affairs Medical Center - Lexington, Lexington, Kentucky, 40502-2236, United States;
Recruiting
Michael A. Doukas, MD 859-281-4956

Louisiana
Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, 71130-3932, United States;
Recruiting
Glenn M. Mills, MD 318-675-7639
gmills@lsuhsc.edu

MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, 70112, United States;
Recruiting
Jill Gilbert, MD 504-568-5136

Tulane University School of Medicine, New Orleans, Louisiana, 70112, United States;
Recruiting
Alan M. Miller, MD, PhD 504-587-7566
amiller@mailhost.tcs.tulane.edu

Veterans Affairs Medical Center - New Orleans, New Orleans, Louisiana, 70112, United States;
Recruiting
German S. Beltran, MD 504-589-5250

Veterans Affairs Medical Center - Shreveport, Shreveport, Louisiana, 71130, United States;
Recruiting
Glenn M. Mills, MD 318-221-8411

Massachusetts
Boston Medical Center, Boston, Massachusetts, 02118, United States; Recruiting
Douglas V. Faller, MD, PhD 617-638-8000

Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain, Massachusetts, 02130, United States;
Recruiting
Michelle Hankins, MD 617-232-9500

Michigan
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, 48201-1379, United States;
Recruiting
Lawrence E. Flaherty, MD 313-745-4700

CCOP - Ann Arbor Regional, Ann Arbor, Michigan, 48106, United States; Recruiting
Philip J. Stella, MD 734-712-1000

CCOP - Beaumont, Royal Oak, Michigan, 48073-6769, United States; Recruiting
David A. Decker, MD 248-551-7695

CCOP - Grand Rapids Clinical Oncology Program, Grand Rapids, Michigan, 49503, United States;
Recruiting
Timothy J. O'Rourke, MD 616-391-1230

Henry Ford Hospital, Detroit, Michigan, 48202, United States;
Recruiting
Robert Anthony
rchapma1@hfhs.org Chapman, MD 313-916-1850


Providence Hospital - Southfield, Southfield, Michigan, 48075-9975, United States;
Recruiting
Anibal Drelichman, MD, MPH, FACP 313-552-0620

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-0912, United States;
Recruiting
Laurence H. Baker, DO, F.A.C.O.I. 734-647-8902
bakerl@umich.edu


Veterans Affairs Medical Center - Ann Arbor, Ann Arbor, Michigan, 48105, United States;
Recruiting
Laurence H. Baker, DO, F.A.C.O.I. 734-769-7100

Veterans Affairs Medical Center - Detroit, Detroit, Michigan, 48201-1932, United States;
Recruiting
Lawrence E. Flaherty, MD 313-576-1000

Minnesota
CCOP - Duluth, Duluth, Minnesota, 55805, United States;
Recruiting
Robert J. Dalton, MD 218-786-8364

Mississippi
Keesler Medical Center - Keesler AFB, Keesler AFB, Mississippi, 39534-2576, United States;
Recruiting
J. David Turner, MD 228-377-6588

University of Mississippi Medical Center, Jackson, Mississippi, 39216-4505, United States;
Recruiting
James Tate Thigpen, MD 601-984-5590
jtthigpen@worldnet.att.net

Veterans Affairs Medical Center - Biloxi, Biloxi, Mississippi, 39531-2410, United States;
Recruiting
Robert Woody Veith, MD 228-523-5000

Veterans Affairs Medical Center - Jackson, Jackson, Mississippi, 39216, United States;
Recruiting
James Tate Thigpen, MD 601-362-4471
Missouri
CCOP - Cancer Research for the Ozarks, Springfield, Missouri, 65807, United States;
Recruiting
John Wendall Goodwin, MD 417-269-4520

CCOP - Kansas City, Kansas City, Missouri, 64131, United States;
Recruiting
Jorge C. Paradelo, MD 816-823-0555

CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri, 63141, United States;
Recruiting
Patrick H. Henry, MD 314-569-6959

St. Louis University Health Sciences Center, Saint Louis, Missouri, 63110, United States;
Recruiting
Paul J. Petruska, MD 314-577-8854
petruspj@slu.edu

Veterans Affairs Medical Center - Kansas City, Kansas City, Missouri, 64128, United States;
Recruiting
Sarah A. Taylor, MD 816-861-4700 ext. 491

Montana
CCOP - Montana Cancer Consortium, Billings, Montana, 59101, United States;
Recruiting
Patrick W. Cobb, MD 406-259-2245

New Mexico
MBCCOP - University of New Mexico HSC, Albuquerque, New Mexico, 87131, United States;
Recruiting
Cheryl L. Willman, MD 505-272-5837

Veterans Affairs Medical Center - Albuquerque, Albuquerque, New Mexico, 87108-5138, United States; Recruiting
Douglas A. Clark, MD 505-265-1711 ext. 2480 clark.douglas@albuquerque.va.gov

New York
Herbert Irving Comprehensive Cancer Center, New York, New York, 10032, United States;
Recruiting
Karen H. Antman, MD 212-305-8602

University of Rochester Medical Center, Rochester, New York, 14642, United States;
Recruiting
Richard I. Fisher, MD 585-275-0842

Veterans Affairs Medical Center - Albany, Albany, New York, 12208, United States;
Recruiting
James Arthur Holland, MD 518-462-3311 Ext: 2328 james.holland3@med.va.gov

Western New York Urology Associates, Buffalo, New York, 14220, United States;
Recruiting
Scott David Perrapato, DO, F.A.C.O.S. 716-828-3369

North Carolina
CCOP - Southeast Cancer Control Consortium, Winston Salem, North Carolina, 27104-4241, United States;
Recruiting
James N. Atkins, MD 336-777-3036

Ohio
Arthur G. James Cancer Hospital - Ohio State University, Columbus, Ohio, 43210-1240, United States;
Recruiting
David E. Schuller, MD 614-293-4878
schuller-l@medctr.osu.edu


Barrett Cancer Center, Cincinnati, Ohio, 45267-0501, United States; Recruiting
Abdul-Rahman Jazieh, MD, MPH 513-584-3830

CCOP - Columbus, Columbus, Ohio, 43206, United States;
Recruiting
J. Philip Kuebler, MD, PhD 614-443-2267

CCOP - Dayton, Kettering, Ohio, 45429, United States;
Recruiting
Howard M. Gross, MD 937-395-8678

Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, 44195-9001, United States;
Recruiting
George Thomas Budd, MD 216-444-6480

Veterans Affairs Medical Center - Cincinnati, Cincinnati, Ohio, 45220-2288, United States;
Recruiting
Abdul-Rahman Jazieh, MD, MPH 513-861-3100 Ext. 6537

Veterans Affairs Medical Center - Dayton, Dayton, Ohio, 45428, United States;
Recruiting
Howard M. Gross, MD 937-268-6511

Oklahoma
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, United States;
Recruiting
Howard Ozer, MD, PhD 405-271-6673

Veterans Affairs Medical Center - Oklahoma City, Oklahoma City, Oklahoma, 73104, United States;
Recruiting
Howard Ozer, MD, PhD 405-270-0501
Oregon
CCOP - Columbia River Program, Portland, Oregon, 97225, United States; Recruiting
Keith S. Lanier, MD 503-216-6260

OHSU Cancer Institute, Portland, Oregon, 97239, United States;
Recruiting
Craig R. Nichols, MD 503-494-1617

Veterans Affairs Medical Center - Portland, Portland, Oregon, 97207, United States;
Recruiting
Craig R. Nichols, MD 503-220-8262

South Carolina
CCOP - Greenville, Greenville, South Carolina, 29615, United States; Recruiting
Jeffrey Kent Giguere, MD 864-241-6251

CCOP - Upstate Carolina, Spartanburg, South Carolina, 29303, United States; Recruiting
James Dewitt Bearden, MD 864-560-6812

Medical University of South Carolina, Charleston, South Carolina, 29425-0721, United States;
Recruiting
Andrew T. Turrisi, MD 843-792-3273

Veterans Affairs Medical Center - Charleston, Charleston, South Carolina, 29401-5799, United States;
Recruiting
Andrew T. Turrisi, MD 843-792-273

Texas
Baylor College of Medicine, Houston, Texas, 77030, United States; Recruiting
Seth P. Lerner, MD 713-798-5906

Brooke Army Medical Center, Fort Sam Houston, Texas, 78234-6200, United States;
Recruiting
Mitchell A. Garrison, MD 210-916-0504 mitchell.garrison@cen.amedd.army.mll

CCOP - Scott and White Hospital, Temple, Texas, 76508, United States; Recruiting
Lucas Wong, MD 254-724-1053

Texas Tech University Health Science Center, Lubbock, Texas, 79415, United States;
Recruiting
Werner T. W. DeRiese, MD 806-743-3133

University of Texas - MD Anderson Cancer Center, Houston, Texas, 77030-4095, United States;
Recruiting
Scott Michael Lippman, MD, FACP 713-745-3672
esparks@mdanderson.org


University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78284-7845, United States;
Recruiting
Geoffrey R. Weiss, MD 210-617-5120
geoffrey.weiss@med.va.gov


University of Texas Medical Branch, Galveston, Texas, 77555-0565, United States;
Recruiting
Robert P. Whitehead, MD 409-772-1164
rpwhiteh@utmb.edu

Veterans Affairs Medical Center - Houston, Houston, Texas, 77030, United States;
Recruiting
Gauri Varadhachary, MD 713-791-1414 Ext. 5340

Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio, Texas, 78284, United States;
Recruiting
Geoffrey R. Weiss, MD 210-617-5300

Veterans Affairs Medical Center - Temple, Temple, Texas, 76504, United States;
Recruiting
Phalguni Mukhopadhyay, MD 254-778-4811 ext. 4809

Utah
Huntsman Cancer Institute, Salt Lake City, Utah, 84112-5550, United States; Recruiting
Wolfram Samlowski, MD 801-585-0255
wolfram.samlowski@hci.utah.edu


Veterans Affairs Medical Center - Salt Lake City, Salt Lake City, Utah, 84148, United States;
Recruiting
Wolfram Samlowski, MD 801-582-1565

Virginia
Eastern Virginia Medical School, Norfolk, Virginia, 23510-1115, United States;
Recruiting
Paul F. Schellhammer, MD 804-628-2409

Washington
CCOP - Northwest, Tacoma, Washington, 98405-0986, United States; Recruiting
Lauren Kenneth Colman, MD 253-403-1461

CCOP - Virginia Mason Research Center, Seattle, Washington, 98101, United States; Recruiting
Andrew David Jacobs, MD 206-341-0446

Madigan Army Medical Center, Tacoma, Washington, 98431-5000, United States; Recruiting
Patrick Williams, MD 253-968-2505
patrick.williams@nw.amedd.army.mil


Swedish Cancer Institute, Seattle, Washington, 98104, United States; Recruiting
Saul E. Rivkin, MD 206-386-2929
saul.rivkin@swedish.org

Veterans Affairs Medical Center - Seattle, Seattle, Washington, 98108, United States;
Recruiting
William H. Schubach, MD 206-764-2709
Study chairs or principal investigators
Linda Garland, MD, Study Chair
Arizona Cancer Center