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Mesothelioma

Experimental Drug SS1(dsFv)-PE38 to Treat Cancer

Experimental Drug SS1(dsFv)-PE38 to Treat Cancer

Background:
This study will determine the dose of the experimental anticancer drug SS1(dsFv)-PE38 that can be given safely to patients. It will also look at how the body handles the drug, its side effects, and its effect on the tumor. SS1(dsFv)-PE38 will be tried in patients with solid tumors that have an antigen called mesothelin. This is a protein that is normally produced by cells lining body cavities, but has also been found on several types of cancer cells. The drug SS1(dsFv)-PE38 is composed of SS1, a protein that binds tightly to mesothelin, and PE38, parts of the Pseudomonas exotoxin (PE) protein, which can kill human cells if it gains entry to them. SS1(dsFv)-PE38 is designed to attach to mesothelin on the cancer cells and allow entry of the PE38, which will then destroy the cells.

Location/Contact Information:
Maryland
National Cancer Institute (NCI), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States;
Recruiting
Clinical Studies Support Center/NCI 1-888-624-1937
ncicssc@mail.nih.gov