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Pericardial mesothelioma is a cancer in the lining that surrounds the heart, called the pericardium. The pericardium are cells that produce a lubricating fluid that protect the heart. They allow the heart to move freely when, for instance, it is pumping blood to other parts of your body.

Pericardial mesothelioma is the least common form of malignant mesothelioma. It only accounts for 5 to 15% of all mesotheliomas.